Succinic acid how to take. Acetylsalicylic acid: instructions for use, analogues and reviews, prices in Russian pharmacies. Instructions for the use of succinic acid in various forms

Succinic acid (sodium succinate, butanedioic acid) is a key biochemical molecule.

Nature uses it for energy metabolism in plants, human tissue and animals. It has been used for centuries as an analgesic and natural antibiotic. Succinates are natural regulators of body processes. The need for them arises with increased stress: both physical and emotional. Acid is unique in that it accumulates only in those areas that need it, bypassing healthy cells and tissues.

The use of succinic acid prevents the development of neoplasms, reduces sugar and neutralizes kidney stones. With varicose veins, butanedioic acid eliminates inflammation, restores blood circulation, and as a result, veins are restored.

Clinical and pharmacological group

Belongs to the group of metabolic drugs and has pronounced antioxidant, metabolic and antihypoxic properties.

Terms of sale from pharmacies

Can buy without a doctor's prescription.

Price

How much does succinic acid cost in pharmacies? The average price is at the level of 190 rubles.

Composition and form of release

Pharmaceutical products containing succinic acid or its compounds are available in tablets, powders, capsules, solutions.

Auxiliary components: talc, sugar, calcium stearate, ascorbic acid, aerosil, starch (potato).

What is succinic acid?

Succinic acid is a natural compound necessary for all living organisms as an active component of organic synthesis. The largest reserves of it on Earth are presented in the form of amber known to all. Amber was the starting material for the production of succinic acid. Modern methods of obtaining it are different - from benzene or n-butane a white powder is obtained, consisting of crystals, sour in taste, soluble in water.

The resulting substance is safe and, what is most valuable, has a positive effect on the human body. In the surrounding world, succinic acid is found in the composition of coal, resins, berries (unripe grapes and gooseberries), turnips, plants (aloe, hawthorn, alfalfa, sugarcane), sunflower seeds and barley. This acid is present in lactic acid products, cheeses, aged wines, flour products made from rye flour, yeast, seafood, etc.

But there are not so many such products, so it is produced by the pharmaceutical industry in various preparations to make up for its deficiency.

Pharmacological effect

Succinic acid is an antioxidant and immunomodulator. It has metabolic, antihypoxic and antioxidant effects. The metabolic effect lies in the fact that a ready-made substance enters the cells, which is included in the Krebs cycle, during which ATP is produced. This effect allows the cells of all organs to receive more energy for their needs, and, therefore, to work more efficiently and better.

The antihypoxic effect of succinic acid is that it improves tissue respiration, that is, the transfer of oxygen from the blood into the cells and its utilization. The antioxidant effect of “amber” is that it neutralizes free radicals that damage cell structures and lead to their death. In addition, due to the antioxidant effect, succinic acid slows down the growth of malignant tumors. Also, succinic acid and its compounds (succinates) have the properties of adaptogens, that is, they improve the overall resistance of the body to negative environmental influences, such as stress, viruses, bacteria, strong psycho-emotional and physical stress, etc.

Succinic acid has the above effects on the cells of any organs and tissues without exception, and therefore improves the condition and functioning of the whole organism as a whole. However, the most pronounced improvement in the background of taking succinic acid is observed in the work of the brain and heart, since these organs use the largest amounts of oxygen and energy. Therefore, succinic acid preparations are successfully used to prevent senile changes in the central nervous system and in the complex therapy of cardiovascular diseases.

The liver under the influence of "amber" quickly neutralizes various toxic substances, due to which any intoxication passes in a short time, including alcohol and nicotine.

In general, we can say that succinic acid has the following effects on the work of various organs and systems:

1. Increases work efficiency and increases the supply of oxygen to the cells of the nervous system;
2. It enhances the therapeutic effects of drugs, due to which it is possible to significantly reduce the dosage and duration of treatment for various diseases;
3. Stops the development and maintenance of the inflammatory process, including allergic, thereby accelerating recovery from chronic diseases;
4. Improves the nutrition of the brain and heart, creating optimal conditions for their work;
5. Accelerates the neutralization of various toxic substances in the liver, due to which any intoxication while taking succinic acid lasts much shorter than without it;
6. Reduces the risk of developing malignant tumors;
7. Reduces the growth rate of tumors;
8. Increases the body's resistance to infections, stress and other adverse environmental influences;
9. Stimulates the production of insulin;
10. Improves blood microcirculation in peripheral tissues (arms, legs, etc.);
11. It has excellent antidepressant properties, helping to relieve irritation, anxiety, fears and negative emotions;
12. Stops chronic inflammatory processes in the genitourinary organs.

Thus, succinic acid is a very useful biologically active additive that promotes the transition to the optimal mode of operation of all organs and tissues.

Indications for use

The use of succinic acid should be agreed with the attending physician. In general, the indications are:

• SARS, influenza, colds (complex forms) - including in children, pregnant women;
• acute bronchitis;
• fibroids, tumors (development prevention);
• chronic stress conditions in humans;
• heart disease and other diseases of the cardiovascular system;
• radiculitis;
• diseases of the reproductive system;
• allergy;
• asthma;
• oncological diseases as an antitoxic agent;
• hangover, alcoholism;
• taking vitamins, drugs to reduce their toxic effects;
• taking food supplements;
• disease prevention in the elderly.

Contraindications

The drug is not allowed to be used by persons who are hypersensitive to the active ingredient - succinic acid. The consumption of the composition is prohibited under the following pathological conditions:

• heart rhythm failures;
• tendency to allergic reactions;
• peptic ulcers of the stomach;
• stones in the kidneys and bile ducts;
• glaucoma.

Appointment during pregnancy and lactation

During breastfeeding, the composition can be used by a woman at a dosage of 1 tablet per day. It is important to monitor the condition of the child, there is a risk of an allergic reaction, because the active ingredient passes into breast milk in some quantities.

Dosage and method of application

As indicated in the instructions for use, tablets of Succinic acid should be taken after meals, drinking plenty of water. The dosage is calculated individually, taking into account the age of the patient and the nature of the disease. In most cases, the drug is taken in the following dosages:

• children under the age of 5 years - three times a day, half a tablet;
• children aged 5 to 12 years - 1 tablet twice a day;
• patients over 18 years of age - three times a day, 0.5-1 tablet.

The average duration of the course of treatment is 30 days. After the first course of treatment, take a break and, if necessary, conduct a second course of treatment with the drug.

Adverse reactions

Effects that may occur while taking the drug:

• gastralgia;
• hypersecretion of gastric juice;
• increased blood pressure (only if there is a tendency to this).

Overdose symptoms

An overdose of succinic acid is impossible.

Compatibility with other drugs

The tool as a whole has good compatibility. Do not combine the intake of succinic acid with anxiolytics and barbiturates.

Succinic acid for weight loss

The positive effect of using succinic acid for weight loss is primarily due to the ability of the substance to cleanse the body of accumulated toxins, activate the function of the digestive system and remove excess water from the body.

Analyzing the reviews of nutritionists about the effectiveness of the remedy, we can conclude that for weight loss it should be used only as an additional stimulant of metabolic processes. Without correcting the diet and exercise, it will not be possible to get rid of subcutaneous fat reserves.

The second option involves taking 1 gram of succinic acid daily for 30 days. The entire dose is taken at one time before breakfast.

Succinic acid and alcohol

Accepted alcohol in the liver very quickly turns into acetaldehyde. The intake of succinic acid accelerates the breakdown of acetaldehyde into substances less harmful to the body, accelerates detoxification and improves overall well-being.

The supplement can be taken:

• before drinking alcohol;
• with a hangover syndrome;
• for the treatment of alcohol withdrawal.

As part of complex therapy, it is possible to use it for alcoholism. Course use for several months is allowed only as directed by a doctor and only after the patient has undergone a comprehensive examination.

The use of succinic acid for a hangover

Many toxicologists tend to consider succinic acid the #1 hangover remedy. By acting on the tricarboxylic acid cycle, which is a key link in energy metabolism, succinate stimulates it in accordance with the principle of mobile balance and promotes the removal of underoxidized metabolic products.

If drinking alcohol was accompanied by a plentiful snack, it is recommended to supplement the use of YAK with enema. To relieve hangover syndrome, it is recommended to take one tablet of 0.1 g every 50 minutes. The maximum daily dose is 6 tablets. Higher doses may cause heartburn.

To prevent a hangover, about an hour before the planned feast, you should take 2 tablets of the supplement. The action develops in half an hour and lasts from 2 to 3 hours.

• Latin name: Succinic acid
• ATX code: V81BF
• Active substance: Succinic acid
• Manufacturer: Elit-pharm LLC, Ukraine Marbiopharm OJSC, Russia

Compound

Mosbiopharm succinic acid tablets contain 100 mg of succinic acid, as well as potato starch, sugar, calcium stearate, talc, aerosil.

The tablets produced by Elit-Pharm contain 150 mg of succinic and 10 mg of ascorbic acid.

Release form

The supplement is available in tablets of 0.1 and 0.25 g in packages No. 40, No. 80 and No. 100 tablets per package.

pharmachologic effect

Antihypoxic, metabolic, antioxidant .

Pharmacodynamics and pharmacokinetics

Succinic acid (SA) is intracellular metabolite of the citrate cycle (Krebs cycle). In the cells of the body performs a universal energy-synthesizing function .

With the participation of the coenzyme FAD (flavin adenine dinucleotide) and under the influence of succinate dehydrogenase (mitochondrial enzyme of the oxidoreductase class), it is rapidly biotransformed into fumaric acid and further into other metabolic products of the Krebs cycle (the end products of UC metabolism are carbon dioxide and water).

Stimulates the breakdown of glucose through the aerobic pathway and the synthesis of ATP, which plays an important role in energy metabolism in the body; due to the activation of electron transport in mitochondria, it improves tissue respiration.

The substance has strong antioxidant properties directed mitochondrial action, which contributes to the rejuvenation of the body at the cellular level.

Widespread use in medicine is due to the ability to stimulate the compensatory-protective and adaptive capabilities of the body; increase the formation of hydrochloric acid and the secretory function of the gastric glands, improve appetite and contractile function of smooth and striated muscles, increase diastolic blood pressure and physical performance.

In addition, by activating intracellular metabolism and cellular respiration, UC promotes the elimination of toxic substances from the body and reduces the toxic effect of alcohol.

When taken orally, YaK penetrates from the digestive tract into tissues and blood, takes part in catabolic reactions, and after half an hour is completely decomposed to the final products of metabolism. The substance does not accumulate in the body. T1 / 2 - about 26 minutes.

Indications for use: what are the tablets of Succinic acid for?

The use of succinic acid in tablets is indicated as a dietary supplement - a source of succinic acid.

The remedy is prescribed for functional asthenic conditions . Its effect is especially strong in age-related ailments and in extreme conditions (including oxygen starvation).

Preparations of succinic acid (SA) help to reduce the manifestations sclerotic changes (forgetfulness, fatigue, etc.) and effectively relieve headaches caused by malnutrition of brain cells.

These properties of YaK make it expedient to use it in ischemic conditions , muscle contractures (muscle stiffness), vasospasm.

Doctors recommend administering UC preparations as an addition to the main therapy for diseases of the heart and blood vessels. Indications for the use of the supplement include: atherosclerotic vascular lesions lower limbs, .

With all these diseases, the patient is forced to take a large number of drugs for a long time (sometimes for life): normalizing heart rhythm, antisclerotic, hypotensive, anticoagulant, vasodilating, potassium-containing, maintaining cholesterol balance, diuretic.

The introduction of UC into the treatment regimen can significantly reduce both the number of drugs taken and the duration of their intake. The effect is achieved due to the pharmacological properties of UC and due to its ability to enhance the effectiveness of primary therapy drugs.

The use of YAK at a dose of up to 1 g / day. provides a distinct potassium-sparing and diuretic effect, which contributes to an increase in daily diuresis and a rapid decrease in edema in patients with various diseases of the circulatory system ( rheumatic defects , ischemic heart disease etc.), and also allows you to significantly reduce the dose cardiac glycosides and diuretic drugs .

The research results are confirmed by ECG dynamics. In all patients who participated in the experiment, after the course use of UC preparations, blood circulation improved in coronary vessels , the heart rate returned to normal, the levels of PTI and in the blood and normalized fraction β-lipoproteins .

A positive effect is also noted in the case of the use of UC preparations in combination with drugs for the treatment dyscirculatory encephalopathy and cerebral atherosclerosis .

Moreover, it becomes noticeable after 3-5 days, and after 2-2.5 months, the manifestations of sclerotic symptoms significantly decrease in patients: dizziness decreases, as well as the intensity and frequency of headaches; improves memory, mood and sleep; increased concentration.

In diseases of the musculoskeletal system (for example, with a deforming or ) in patients taking YaK, pain, swelling and deformity of the joints decrease, their mobility increases and, in addition, the concentration of uric acid in the blood decreases.

Studies on the use of the supplement in patients with bronchopulmonary pathologies showed that the appointment of a patient from 0.5 to 1.5 g of UC per day improves overall health and prolongs the period of remission. Changes are also noted in indicators of the state of the immune status, both in the cellular and in the humoral link.

Prophylactic use of UC preparations in a 2-3-week course during periods of seasonal exacerbations of chronic diseases makes it possible to ensure that even if the patient does fall ill, the disease proceeds in a milder form, and recovery occurs much faster.

Taking high doses of YAK during ARVI and influenza prevents the development of the disease and allows you to restore your ability to work within a few days.

Succinates regulate the production , which contributes to the restoration of the metabolism of saccharides. This property allows the use of UC for the prevention and treatment non-insulin dependent diabetes .

Increased secretion insulin due to the fact that YAK activates enzymes independent of the level of dextrose in the body.

UC prevents genetic disorders that are a consequence of the influence of carcinogens and lead to uncontrolled cell division. The use of supplements with succinates allows several times to reduce the mortality of cancer patients and improve their quality of life.

It has been experimentally proven that succinates inhibit the growth of neoplasms. Accumulating mainly at the site of tumor formation, UC prevents reproduction malignant cells .

In addition, the drug helps to reduce the severity of side effects of chemotherapy: loss of strength, depression, nausea.

The positive effect of the use of UC is most pronounced when , , cysts and others benign tumors .

Special attention deserves the use of YaK in geriatric patients , which in the vast majority of cases have a complex pathology.

The benefit for the body of an elderly person is that taking YAK tablets can reduce the severity of symptoms of age-related diseases and at the same time reduce the amount and dose of pharmacological preparations they need.

The greatest efficiency is noted when using UC in combination with agents that restore intestinal microflora . This combination improves immune status , while in patients there is a clear trend towards normalization of the serum concentration of malonic dialdehyde and the severity of endogenous intoxication decreases.

For preventive purposes, YaK can also be taken by healthy people. The introduction of the supplement into the diet of athletes makes it easier to adapt to ever-increasing loads and relieve pain in the muscles after an intense workout.

Also, the tool is used for intoxication of various etiologies (including alcohol and drugs).

Contraindications for succinic acid

Succinates are natural substances for the human body, therefore, even with prolonged use, they do not cause side effects and dependence.

However, UC preparations have contraindications. Tablets are not prescribed for:

• during its exacerbation (succinates strongly irritate the mucous membrane of the digestive tract);
• gastritis with hypersecretion ;
• high blood pressure ;
• urolithiasis (YAK stimulates metabolism, which leads to more intense formation of oxalate stones);
• severe form of gestosis of pregnant women ;

YaK excites the brain (the drug has an effect opposite to the action of tranquilizers and glycine), so you should not take pills at night.

Side effects

hypersensitivity reactions, gastralgia , hypersecretion of gastric juice . Those prone to arterial hypertension people against the background of the systematic use of UC drugs, it is possible increase in blood pressure .

Succinic acid tablets: instructions for use

In accordance with the instructions for use, succinic acid is taken before meals, previously dissolved in fruit / berry juice or mineral water.

The daily dose for an adult is 0.5-3 tablets. The duration of the course is 4 weeks.

During pregnancy, the dose depends on the period. For a period of 12-14 weeks, pregnant women are prescribed the supplement to take 0.25 g per day for a ten-day course. In the second trimester, it is advisable to drink the drug between 24 and 26 weeks, in the third - about 10-25 days before delivery. During the entire period of pregnancy, it is allowed to take no more than 7.5 grams of UC.

For the prevention of poisoning with alcohol decay products, it is recommended to take 0.25 g of YaK half an hour or an hour before drinking alcohol. With alcohol withdrawal, treatment is continued for 4 to 10 days. The daily dose is 0.75-1 g of UC divided into 3-4 doses. The supplement can be taken as an independent agent, or in combination with other pharmacological preparations.

To improve appetite, it is indicated to take 0.25 g of YaK from 1 to 3 times a day, before meals. If the supplement is accompanied by a feeling of heaviness in the epigastric region, the tablets are drunk after meals. The duration of the course is from 3 to 5 days.

As an irritant of the gastric glands, before examining the secretory ability of the stomach, UC is taken on an empty stomach, 1 tablet, after dissolving it in a dessert or a tablespoon of water. The study is carried out at standard time intervals using conventional methods of analysis.

Cancer patients for preventive purposes, a daily intake of 2-3 tablets of 0.1 g is indicated. If necessary, the dose is increased to 5-10, and in especially severe cases - up to 20 tablets per day.

During periods of exacerbation of seasonal diseases, UC is taken for prophylaxis twice a day, 0.5 g each, for a course of 2-3 weeks. With influenza and SARS at the initial stages of the development of the disease, tablets are taken 1 or 2 times a day, 3-4 pieces per dose. With hyperthermia, UC should be drunk in combination with .

The use of YAK in cosmetology allows you to slow down the aging of the skin, cleanse it at the cellular level and whiten it, remove scars, acne and swelling, remove toxins and saturate it with oxygen.

For the skin of the face, neck, décolleté and skin around the eyes, it is used in serums, masks, lotions, creams, peels. Cosmetics with the addition of YaK is used in almost all anti-aging programs.

To prepare a cream with YAK, it is enough to add a tablet dissolved in a teaspoon of flower water to 20 ml of a cream suitable for your skin type. To completely dissolve the tablet, it is left in water for several hours.

To make a mask, you just need to apply on the skin crushed into powder and mixed with flower water to the consistency of thick sour cream, YAK tablets. After 15-20 minutes, the mixture is washed off and a cream is applied to the skin. For women with dry skin, the procedure can be repeated no more than once a week; for oily skin, the mask can be done three times a week.

To prepare the tonic, mix the following components: fragrant water (50 ml), 10 drops of ylang-ylang and rosemary oils, 2 YAK tablets, crushed into powder, benzyl alcohol (0.5 ml). Alcohol acts as a preservative. If the tonic will be stored for a short time (no more than 7 days) and in the refrigerator, you can not add it.

To make scars and stretch marks less noticeable, you should prepare a thick mixture of flower water and yak, apply it to the problem area and massage for 1-2 minutes. After 15 minutes, you can wash off the remnants of the peeling mass and apply cream or milk to the skin.

No less useful for stretch marks and a mask with mummy. To prepare it, several tablets and several tablets of YAK are dissolved in a small amount of olive or almond oil. When the mass becomes homogeneous, it is applied to problem areas and the skin is massaged well. After an hour, the mask is washed off with cool water.

The result is noticeable with systematic use. It is considered optimal to do the procedures daily for 3 weeks, then take a break and, if necessary, repeat the course.

The use of YAK for hair helps to increase blood flow to the scalp, strengthens the hair, makes it more hydrated, shiny and manageable.

The product can be added to regular shampoos and masks, or it can be rubbed into the scalp, after soaking in a small amount of water / hydrolat. After applying the gruel to the hair, wrap the head with a towel for 2 hours (you can leave the mask for longer). The procedures are repeated daily for a month.

Overdose

An overdose of succinic acid is impossible.

Interaction

Succinic acid is compatible with most pharmacological agents. The exception is anxiolytics and barbiturates (succinates reduce their effectiveness).

Can be used as an adjuvant in complex therapy infectious diseases to reduce the toxic effects of other drugs, including antibiotics , antihelminthic, tuberculosis and anti-inflammatory drugs .

Terms of sale

The tool is sold without a prescription.

Storage conditions

Keep the drug out of the reach of children, protected from moisture at temperatures up to 25 ° C.

Shelf life

Tablets are suitable for use within 4 years after the date of issue.

special instructions

What is succinic acid and why does the body need succinates?

Succinic or butanedioic acid is a dibasic carboxylic acid, which has the appearance of colorless crystals and is highly soluble in alcohol and water.

In small quantities, this organic compound is found in some vegetables and fruits, but its main source for medicine, food and chemical industries is natural amber.

The chemical formula of the substance is HOOC-CH2-CH2-COOH.

According to Wikipedia, succinate is involved in tissue respiration in oxygen-breathing organisms.

The benefits and harms of succinic acid

The most valuable properties of YaK are its ability to facilitate the adaptation of the body to stressful situations and protect it from various kinds of toxic poisoning.

This allows you to effectively use the supplement as an addition to the main therapy for a fairly wide range of diseases.

However, with uncontrolled use of YaK can harm the body. The tool has a number of contraindications and is not intended for systematic daily use. As a rule, the supplement is drunk for no more than 4 weeks.

The use of succinic acid in crop production

For plants, succinic acid is an antistress agent and a growth stimulator.

The use of succinic acid for plants is possible in several ways. For seedlings, spraying of all parts of the plant (roots, leaves, stems) is shown, as well as soaking the roots before planting for 0.5-4 hours (after soaking, the roots are dried for half an hour, and then the plants are planted in the ground).

For flowers, the solution is an intensive care agent: they are watered with the roots of the plant and sprayed with the aerial parts of the plant.

In case of problems with the turgor of the tops for flowers (and, in particular, for orchids), a solution of succinic acid with glucose, nicotinic acid and vitamin B1 is used (1 tablet of each component per 1 liter of water).

To prepare a solution for irrigation, 1-2 tablets (sometimes 4) are poured with a liter of hot water, and then cooled. For indoor plants, treatment with such a “medicine” should be carried out no more than once a month.

Analogues

Amber antitox , Succinic acid-Elit-pharm , Complex “Inosine + Nicotinamide + Riboflavin + Succinic Acid” , Amber , Mitomin , Yantavit , Brewer's yeast with succinic acid .

Succinic acid and alcohol

Accepted alcohol in the liver very quickly turns into acetaldehyde. The intake of succinic acid accelerates the breakdown of acetaldehyde into substances less harmful to the body, accelerates detoxification and improves overall well-being.

The supplement can be taken:

• before drinking alcohol;
• with a hangover syndrome;
• for treatment alcohol withdrawal .

As part of complex therapy, it is possible to use it for alcoholism. Course use for several months is allowed only as directed by a doctor and only after the patient has undergone a comprehensive examination.

The use of succinic acid for a hangover

Many toxicologists tend to consider succinic acid the #1 hangover remedy. By acting on the tricarboxylic acid cycle, which is a key link in energy metabolism, succinate stimulates it in accordance with the principle of mobile balance and promotes the removal of underoxidized metabolic products.

If drinking alcohol was accompanied by a plentiful snack, it is recommended to supplement the use of YAK with enema.

To prevent a hangover, about an hour before the planned feast, you should take 2 tablets of the supplement. The action develops in half an hour and lasts from 2 to 3 hours.

Succinic acid for weight loss

The positive effect of using succinic acid for weight loss is primarily due to the ability of the substance to cleanse the body of accumulated toxins, activate the function of the digestive system and remove excess water from the body.

Analyzing the reviews of nutritionists about the effectiveness of the remedy, we can conclude that for weight loss it should be used only as an additional stimulant of metabolic processes. Without correcting the diet and exercise, it will not be possible to get rid of subcutaneous fat reserves.

The second option involves taking 1 gram of succinic acid daily for 30 days. The entire dose is taken at one time before breakfast.

Application during pregnancy

The use of succinates during pregnancy facilitates the hormonal restructuring of the female body, helps to strengthen immune system , as well as a decrease in the frequency and severity , prevents loss of strength and complications of pregnancy, helps to compensate for increased energy costs, ensures the creation of an environment that is optimal for the development of the fetus, in which the latter is sufficiently provided with nutrients and oxygen.

Yak acid helps to strengthen histohematic barrier between the blood and the fetus, which in turn helps protect the fetus from the effects of pathogens and toxins.

Thus, the risk of having a child with congenital diseases or malformations is significantly reduced.

It is important to remember that during the entire period of pregnancy it is contraindicated to take more than 7.5 g of YaK.

Succinic acid (sodium succinate, butanedioic acid) is a key biochemical molecule. Nature uses it for energy metabolism in plants, human tissue and animals. It has been used for centuries as an analgesic and natural antibiotic.

Succinates are natural regulators of body processes. The need for them arises with increased stress: both physical and emotional. Acid is unique in that it accumulates only in those areas that need it, bypassing healthy cells and tissues.

It can be purchased in pharmacies in the form of tablets. It is a colorless crystalline solid and is a product of amber processing. How useful is succinic acid and how important is it for the human body?

Amber is an antioxidant that can help with heart rhythm disorders, it improves blood circulation and the functioning of the urinary system.

A proven fact - succinic acid has a positive effect on the restoration of the nervous and immune systems, increases the body's resistance to infections, and also helps to compensate for the leakage of energy in the body and brain, increasing attention, concentration and reflexes and reducing stress.

The use of succinic acid prevents the development of neoplasms, reduces sugar and neutralizes kidney stones. With varicose veins, butanedioic acid eliminates inflammation, restores blood circulation, and as a result, veins are restored.

Succinic acid is one of the natural acids found in foods such as broccoli, rhubarb, sugar beets, unripe gooseberries and grapes, fresh meat extracts, various cheeses, and sauerkraut.

All of these products have very distinct and noticeable flavors which may be due in part to the enhancement of taste by small amounts of naturally occurring succinic acid.

Succinic acid is an acidity regulator and also a flavoring agent. It can be present in sweets, baked goods, etc. In addition, it is present in oysters, hard cheeses, yoghurts, sunflower seeds, strawberries, wine, hawthorn, nettles.

The required amount of acid for an adult is 200 mg per day. And if a person does not eat enough food with acid, then he needs to use it as a food supplement.

Indications for use

The use of succinic acid should be agreed with the attending physician. Generally indications are:

• chronic stress conditions in humans;
• heart disease and other diseases of the cardiovascular system;
• anemia;
• radiculitis;
• diseases of the reproductive system;
• allergy;
• asthma;
• SARS, influenza, colds (complex forms) - including in children, pregnant women;
• acute bronchitis;
• fibroids, tumors (development prevention);
• oncological diseases as an antitoxic agent;
• hangover, alcoholism;
• taking vitamins, drugs to reduce their toxic effects;
• taking food supplements;
• disease prevention in the elderly.

This substance is considered harmless, but, despite this, you should not self-medicate. Before you start taking, you should consult with your doctor. The specialist may prescribe a course of tablets or a solution. It is usually recommended to start with 500 mg in the morning with plenty of water.

As soon as the effect is noticeable, the daily dose can be reduced to 200 mg per day. If there is no improvement, then the dose should be increased, but also after consultation with your doctor.

Excessive consumption of succinic acid can harm health, not improve it, so it is recommended to be monitored by a doctor. And read the instructions for use.

Succinic acid: contraindications

In some people, this substance can cause severe heartburn or irritate the walls of the stomach, in addition, the drug not recommended for people diagnosed with:

• ulcers of the gastrointestinal tract (the substance can lead to an increase in the secretion of gastric juice);
• hypertension, glaucoma, coronary heart disease (the drug may increase blood pressure);
• individual intolerance, drug allergy.

Weightloss remedy

In bodybuilding, and as a weight loss aid, sodium succinate is the number one helper. Acid normalizes the functions of organs, has a beneficial effect on the entire body, and it, in turn, fights excess weight. People not only lose weight, but are also treated in the process of taking.

It improves metabolism, cleanses the body of toxins and waste products at the cellular level. This increases the level of oxygen and energy in the cells; increases resistance to stress, increases the body's resistance to stress and reduces fatigue during exercise.

The duration of the course is agreed with the doctor.

Succinic acid in oncology

In Moscow, at the Institute of Biophysics, studies were conducted with the participation of volunteers: in addition to the use of acid, the subjects followed a diet, consumed herbs, vitamin and mineral complexes, and healing drinks. The results were processed over several years.

It was found that the use of succinic acid stops the growth of tumors, and different ones: cancer of the ovaries, mammary glands, cervix, colon.

With the use of standard methods of treatment - operations, chemotherapy, radiation, and in addition acid - the chances of a cure increase by 2-3 times. It also helps to alleviate conditions associated with toxicosis after chemotherapy.

This substance helps to cope with acne, normalizes cells, stimulates and activates metabolism, removes toxins, restores elasticity and freshness of the skin, complexion. Improves nutrition of skin cells, reduces scars, bags under the eyes, reduces wrinkles.

Grind 2 tablets of succinic acid, pour the resulting powder with 1 tablespoon of water, mix. Apply to the face (avoiding the eyes), do not rinse, the mixture should be completely absorbed. Repeat every week.

In addition, succinate peels are popular in cosmetology. They are indicated for people whose skin is prone to acne, as well as sensitivity and rosacea. Peeling strengthens blood vessels and restores blood microcirculation.

The frequency of the procedure depends on the type of skin. It can be carried out in a beauty parlor, or you can do it yourself. This tool is effective in the fight against cellulite, it helps to even out the skin texture and reduces stretch marks.

Succinate molecules are injected subcutaneously, which allows you to influence the problem locally.

It enhances metabolic processes in cells. Injection is the most effective, as it affects the deep layers of the skin. It is used in combination with hyaluronic acid, activating the metabolism in cells.

Interaction with other drugs

The compatibility of sodium succinate with other drugs has been proven. It can be taken with many medications, but it reduces the effects of barbiturates and anxiolytics.

Use during pregnancy

During pregnancy, the body experiences severe stress, and here butanedioic acid will be an assistant and savior. It helps to increase the oxygen metabolism of the body and provides nutrients to the unborn child. Reduces predisposition to stress and anxiety.

Accelerates the excretion of toxins from the body. Reduces the risk of anemia. Use during pregnancy and lactation is recommended by doctors in small doses, not more than 250 mg per day.

Before use, consultation with a treating specialist is necessary.

Taking pills inside helps to improve the structure of the hair, their condition, accelerates growth and prevents hair loss.

In addition, you can supplement the use of tablets with external use. You can add the crushed agent to the rinsing balm. Or apply to the hair, after washing the head, having previously dissolved 3-4 tablets. You can also add the product to the shampoo.

It is recommended to mix crushed tablets with olive oil, apply to clean hair, hold for 10-15 minutes, like a mask, cover your head with a towel, then rinse. You can carry out this procedure once a week until the hair acquires a healthy, radiant appearance and stops falling out.

Succinic acid is a unique remedy that is used both in medicine and cosmetology, helps to fight serious diseases, has a preventive effect, affects various functions of the body: both physical and psycho-emotional.

But you should always remember that acid, like any remedy, may have contraindications, so it is recommended to consult a doctor before taking succinate.

(butanedioic acid or sodium succinate) is one of the most important biochemical molecules necessary for energy exchange in human, animal and plant tissues. In medicine, it is used as a natural antibiotic and analgesic.

Succinates act as natural regulators in the body. The need for them appears during an increase in physical or mental stress. The uniqueness of succinates lies in the fact that they accumulate exactly in those body systems in which they are needed, and do not affect normally functioning tissues or cells in any way.

What is useful succinic acid:

• reduces blood sugar;
• destroys kidney stones;
• prevents the development of tumors;
• has an anti-inflammatory effect in varicose veins.

Where is sodium succinate found

Succinic acid is a natural compound essential for all living organisms, as it plays an active role in organic synthesis. Its largest reserve on our planet is in the form of the well-known amber, which is the starting material for the production of sodium succinate.

However, today there are other ways to obtain this compound: a white crystalline powder is produced from benzene or n-butane, which has a sour taste and is highly soluble in water. It is absolutely safe for the body and has the same properties that are necessary to maintain human health.

In nature, succinic acid is found in turnips, resins, coal, unripe berries, sunflower seeds, barley, and some other plants. It is also present in aged wines, cheeses, dairy products, seafood and yeast.

Thus, the list is not so long, and therefore succinic acid is produced on an industrial scale.

Pharmacological group

• Metabolic drug, has a pronounced antihypoxic and antioxidant effect.

Pharmacokinetics

Succinic acid is a natural immunomodulator, has the following properties:

1. Antihypoxic (increased oxygen metabolism in tissues);
2. Antioxidant (neutralization of free radicals that destroy the cellular structure);
3. Adaptogenic (increases the body's resistance to negative stimuli from the external environment);
4. Metabolic (the active substance contributes to the production of adenosine triphosphate, which is necessary for the efficient functioning of cells).

Succinic acid affects all cells of the body, thereby contributing to a general improvement in the condition and more active functioning of all systems of the human body.

But succinate has the greatest effect on the heart and brain. In this regard, drugs based on succinic acid are used in the treatment of cardiovascular diseases, as well as the prevention of senile changes in the central nervous system. In addition, under the influence of succinates, the liver quickly neutralizes harmful and dangerous substances, thereby reducing the period of intoxication.

Thus, succinic acid has the following useful properties:

1. Improves the functioning of CNS cells by enriching them with oxygen;
2. Reduces the period of therapy and reduces the dose of drugs due to its ability to enhance the therapeutic effect;
3. Stops inflammation processes, as well as allergies;
4. Improves the nutrition of heart and brain cells with oxygen;
5. Accelerates the work of the liver, which is important during the period of intoxication;
6. Increases the body's resistance to infections;
7. Inhibits the growth of tumors, reduces the risk of malignant tumors;
8. Stimulates the production of insulin;
9. Increases blood circulation in peripheral tissues;
10. Stops inflammation in the pelvic organs;
11. It is a natural antidepressant.

Terms of sale

• Leave without a doctor's prescription.

Storage

• Store in a dry dark place at a temperature not exceeding 25 ºС. Keep away from children.
• Shelf life from the date of issue: 4 years.

Price

The price of succinic acid is within 190 rubles.

Release form

Succinic acid is available in tablet form, as well as in the form of capsules, powder, solution.

The preparations based on succinic acid may contain auxiliary components: ascorbic acid, calcium stearate, potato starch, talc, glucose, aerosil.

Indications for taking succinic acid are:

1. cold, acute respiratory viral infection, flu, acute bronchitis;
2. diseases of the heart and blood vessels;
3. diseases of the reproductive system;
4. allergy;
5. chronic stress;
6. asthma;
7. oncology;
8. prevention of fibroids and tumors;
9. radiculitis;
10. anemia;
11. hangover, alcoholism;
12. disease prevention in the elderly;
13. taking medications (to reduce the likelihood of side effects).

Succinic acid can bring both benefit and harm, and therefore it is necessary to consult a doctor before using it.

Contraindications

Succinic acid should not be used by people in the presence of:

1. stomach ulcers;
2. allergies to sodium succinate or a tendency to allergic reactions to other substances;
3. arterial hypertension;
4. failures in the heart rhythm;
5. glaucoma;
6. urolithiasis.

Instructions for the use of succinic acid

In order to properly use succinic acid, it is necessary to consult with your doctor, as the dosage is calculated individually, based on the patient's age and type of disease.

• children under 5 years old- 3 times a day, half a tablet (can be crushed and diluted with water);
• children 5-12 years old- 2 times a day, 1 tablet;
• adults- 3 times a day, 0.5-1 tablet.

It is necessary to take the medicine after a meal, diluting it in water or drinking plenty of liquid.

Course duration: 30 days. After that, you need a break. Further, if necessary, a second course is possible.

How to take during pregnancy and lactation

The use of succinic acid for women during lactation should not exceed 1 tablet per day. In this case, it is necessary to monitor the condition of the child, since the active substance can provoke allergies.

Adverse reactions

When taking succinic acid, the following adverse reactions may occur:

1. increased production of gastric juice;
2. a jump in blood pressure (in people who already have disorders of the cardiovascular system);
3. cramping pains in the stomach.

Cases of overdose with succinic acid have not been identified.

Compatibility with alcohol and other drugs

• Succinic acid cannot be combined with barbiturates and anxiolytics.

Succinic acid contributes to the speedy breakdown of alcohol into substances harmless to the body, thereby accelerating the process of detoxification. Taking the drug is possible before drinking alcohol, with a hangover, as well as during the removal of withdrawal symptoms. As part of complex therapy, sodium succinate is prescribed in the treatment of alcoholism.

What is succinic acid for during a hangover

Most toxicologists consider succinic acid to be the first remedy for a hangover. Sodium succinate stimulates tricarboxylic acids, which are an important part of energy metabolism in the human body, thereby accelerating the elimination of alcohol decay products. In the case of drinking alcohol with a large number of snacks, it is recommended to use an enema as an additional measure.

How to use succinic acid for a hangover:

• to relieve the syndrome, drink 1 tablet (0.1 g) every 50 minutes, daily dose - no more than 6 tablets;
• to prevent the syndrome, 1 hour before the feast, take 2 tablets (the action lasts 2-3 hours).

Sodium Succinate for Weight Loss

The effect of losing weight when taking succinic acid is explained by its ability to remove harmful substances, excess fluid from the body, and also activate the digestive system. However, you should not use succinic acid without diet and sports, as it is only a metabolic stimulant.

Those who want to lose weight should take succinic acid as an additive according to one of the following schemes:

• 3 days in a row, 3-4 tablets per day, on the 4th day arrange unloading (do not take the drug, limit food intake, take a break from exercise);
• daily for a month, take 1 gram of succinic acid (the entire dose before the morning meal).

Sodium Succinate for Flowers

Succinic acid can serve as a natural flower food, as it is found in small amounts in many living organisms. For these purposes, a 1% solution must be prepared from sodium succinate (dilute 1 g of acid with a small amount of warm water, stir until the powder is completely dissolved, then pour in 1 liter of cold water). This solution can be used to spray orchids.

Acetylsalicylic acid (acetylsalicylic acid)

Composition and form of release of the drug

◊ Pills white, flat-cylindrical, slightly marbled, with a notch and chamfer, odorless or with a slight characteristic odor.

Excipients: potato starch - 91 mg, talc - 9 mg.

10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (5) - packs of cardboard.
10 pieces. - cellular contour packings (10) - packs of cardboard.
10 pieces. - cellular contour packings (20) - packs of cardboard.
10 pieces. - cellular contour packs (300) - cardboard packs (for hospitals).
10 pieces. - cellular contour packs (500) - cardboard packs (for hospitals).
20 pcs. - polymer cans (1) - packs of cardboard.
20 pcs. - polymer cans (30) - cardboard packs (for hospitals).
20 pcs. - polymer cans (40) - cardboard packs (for hospitals).
30 pcs. - polymer cans (1) - packs of cardboard.
30 pcs. - polymer cans (30) - cardboard packs (for hospitals).
30 pcs. - polymer cans (40) - cardboard packs (for hospitals).

pharmachologic effect

NSAIDs. It has anti-inflammatory, analgesic and antipyretic effects, and also inhibits platelet aggregation. The mechanism of action is associated with the inhibition of the activity of COX, the main enzyme of the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. A decrease in the content of prostaglandins (mainly E 1) in the center of thermoregulation leads to a decrease in body temperature due to the expansion of skin vessels and an increase in sweating. The analgesic effect is due to both central and peripheral action. Reduces aggregation, adhesion of platelets and thrombosis by suppressing the synthesis of thromboxane A 2 in platelets.

Reduces mortality and the risk of myocardial infarction in unstable angina. It is effective in the primary prevention of diseases of the cardiovascular system and in the secondary prevention of myocardial infarction. In a daily dose of 6 g or more, it inhibits the synthesis of prothrombin in the liver and increases the prothrombin time. Increases fibrinolytic activity and reduces the concentration of vitamin K-dependent coagulation factors (II, VII, IX, X). Increases hemorrhagic complications during surgical interventions, increases the risk of bleeding during therapy. Stimulates the excretion of uric acid (impairs its reabsorption in the renal tubules), but in high doses. Blockade of COX-1 in the gastric mucosa leads to inhibition of gastroprotective prostaglandins, which can lead to mucosal ulceration and subsequent bleeding.

Pharmacokinetics

When taken orally, it is rapidly absorbed mainly from the proximal small intestine and, to a lesser extent, from the stomach. The presence of food in the stomach significantly alters the absorption of acetylsalicylic acid.

It is metabolized in the liver by hydrolysis to form followed by conjugation with glycine or glucuronide. The concentration of salicylates in plasma is variable.

About 80% of salicylic acid binds to plasma proteins. Salicylates easily penetrate into many tissues and body fluids, incl. into the cerebrospinal, peritoneal and synovial fluids. Small amounts of salicylates are found in the brain tissue, traces - in bile, sweat, feces. It quickly crosses the placental barrier and is excreted in small amounts in breast milk.

In newborns, salicylates can displace bilirubin from its association with albumin and contribute to the development of bilirubin encephalopathy.

Penetration into the joint cavity accelerates in the presence of hyperemia and edema and slows down in the proliferative phase of inflammation.

When acidosis occurs, most of the salicylate turns into non-ionized acid, which penetrates well into tissues, incl. into the brain.

It is excreted mainly by active secretion in the tubules of the kidneys in unchanged form (60%) and in the form of metabolites. The excretion of unchanged salicylate depends on the pH of the urine (with alkalization of the urine, the ionization of salicylates increases, their reabsorption worsens, and excretion increases significantly). T 1/2 acetylsalicylic acid is approximately 15 minutes. T 1 / 2 salicylate when taken in low doses is 2-3 hours, with increasing doses it can increase up to 15-30 hours. In newborns, the elimination of salicylate is much slower than in adults.

Indications

Rheumatism, rheumatoid arthritis, infectious-allergic myocarditis; fever in infectious and inflammatory diseases; pain syndrome of low and medium intensity of various origins (including neuralgia, myalgia, headache); prevention of thrombosis and embolism; primary and secondary prevention of myocardial infarction; prevention of cerebrovascular accidents by ischemic type.

In clinical immunology and allergology: in gradually increasing doses for prolonged "aspirin" desensitization and the formation of stable tolerance to NSAIDs in patients with "aspirin" asthma and the "aspirin triad".

Contraindications

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, gastrointestinal bleeding, "aspirin triad", a history of indications of urticaria, rhinitis caused by taking acetylsalicylic acid and other NSAIDs, hemophilia, hemorrhagic diathesis, hypoprothrombinemia, dissecting aortic aneurysm, portal hypertension, vitamin K deficiency, liver and / or kidney failure, glucose-6-phosphate dehydrogenase deficiency, Reye's syndrome, children's age (up to 15 years - the risk of developing Reye's syndrome in children with hyperthermia on the background of viral diseases), I and III trimesters of pregnancy, lactation period , hypersensitivity to acetylsalicylic acid and other salicylates.

Dosage

Individual. For adults, a single dose varies from 40 mg to 1 g, daily - from 150 mg to 8 g; multiplicity of application - 2-6 times / day.

Side effects

From the digestive system: nausea, vomiting, anorexia, epigastric pain, diarrhea; rarely - the occurrence of erosive and ulcerative lesions, bleeding from the gastrointestinal tract, impaired liver function.

From the side of the central nervous system: with prolonged use, dizziness, headache, reversible visual impairment, tinnitus, aseptic meningitis are possible.

From the hematopoietic system: rarely - thrombocytopenia, anemia.

From the blood coagulation system: rarely - hemorrhagic syndrome, prolongation of bleeding time.

From the urinary system: rarely - impaired renal function; with prolonged use - acute renal failure, nephrotic syndrome.

Allergic reactions: rarely - skin rash, Quincke's edema, bronchospasm, "aspirin triad" (combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid and pyrazolone drugs).

Others: in some cases - Reye's syndrome; with prolonged use - increased symptoms of chronic heart failure.

drug interaction

With the simultaneous use of antacids containing magnesium and / or aluminum hydroxide, slow down and reduce the absorption of acetylsalicylic acid.

With the simultaneous use of drugs that limit the intake of calcium or increase the excretion of calcium from the body, the risk of bleeding increases.

With simultaneous use with acetylsalicylic acid, the effect of heparin and indirect anticoagulants, hypoglycemic agents of sulfonylurea derivatives, insulins, methotrexate, phenytoin, is enhanced.

With simultaneous use with GCS, the risk of ulcerogenic action and the occurrence of gastrointestinal bleeding increases.

With simultaneous use, the effectiveness of diuretics (spironolactone, furosemide) decreases.

With the simultaneous use of other NSAIDs, the risk of side effects increases. Acetylsalicylic acid may reduce plasma concentrations of indomethacin, piroxicam.

When used simultaneously with gold preparations, acetylsalicylic acid can induce liver damage.

With simultaneous use, the effectiveness of uricosuric agents (including probenecid, sulfinpyrazone, benzbromarone) decreases.

With the simultaneous use of acetylsalicylic acid and sodium alendronate, severe esophagitis may develop.

With the simultaneous use of griseofulvin, a violation of the absorption of acetylsalicylic acid is possible.

A case of spontaneous hemorrhage in the iris is described when taking the extract against the background of long-term use of acetylsalicylic acid at a dose of 325 mg / day. It is believed that this may be due to an additive inhibitory effect on platelet aggregation.

With the simultaneous use of dipyridamole, an increase in Cmax of salicylate in plasma and AUC is possible.

With simultaneous use with acetylsalicylic acid, the concentrations of digoxin, barbiturates and lithium salts in the blood plasma increase.

With the simultaneous use of salicylates in high doses with inhibitors of carbonic anhydrase, intoxication with salicylates is possible.

Acetylsalicylic acid at doses less than 300 mg / day has little effect on the effectiveness of captopril and enalapril. When using acetylsalicylic acid in high doses, it is possible to reduce the effectiveness of captopril and enalapril.

With simultaneous use, caffeine increases the absorption rate, plasma concentration and bioavailability of acetylsalicylic acid.

With simultaneous use, metoprolol can increase the Cmax of salicylate in plasma.

When using pentazocine against the background of long-term use of acetylsalicylic acid in high doses, there is a risk of developing severe adverse reactions from the kidneys.

With the simultaneous use of phenylbutazone reduces uricosuria caused by acetylsalicylic acid.

With simultaneous use, ethanol can enhance the effect of acetylsalicylic acid on the gastrointestinal tract.

special instructions

Use with caution in patients with diseases of the liver and kidneys, with bronchial asthma, erosive and ulcerative lesions and bleeding from the gastrointestinal tract in history, with increased bleeding or while conducting anticoagulant therapy, decompensated chronic heart failure.

Acetylsalicylic acid, even in small doses, reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients. When carrying out long-term therapy and / or the use of acetylsalicylic acid in high doses, a doctor's supervision and regular monitoring of hemoglobin levels are required.

The use of acetylsalicylic acid as an anti-inflammatory agent in a daily dose of 5-8 g is limited due to the high likelihood of side effects from the gastrointestinal tract.

Before surgery, to reduce bleeding during surgery and in the postoperative period, salicylates should be discontinued 5-7 days in advance.

During long-term therapy, it is necessary to conduct a complete blood count and a study of feces for occult blood.

The use of acetylsalicylic acid in pediatrics is contraindicated, since in the case of a viral infection in children under the influence of acetylsalicylic acid, the risk of developing Reye's syndrome increases. Symptoms of Reye's syndrome are prolonged vomiting, acute encephalopathy, liver enlargement.

The duration of treatment (without consulting a doctor) should not exceed 7 days when prescribed as an analgesic and more than 3 days as an antipyretic.

During the treatment period, the patient should refrain from drinking alcohol.

Pregnancy and lactation

Contraindicated for use in the I and III trimesters of pregnancy. In the II trimester of pregnancy, a single dose is possible according to strict indications.

It has a teratogenic effect: when used in the first trimester, it leads to the development of a splitting of the upper palate, in the third trimester it causes inhibition of labor activity (inhibition of prostaglandin synthesis), premature closure of the ductus arteriosus in the fetus, pulmonary vascular hyperplasia and hypertension in the pulmonary circulation.

Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in the child due to impaired platelet function, therefore, acetylsalicylic acid should not be used in the mother during lactation.

Application in childhood

Contraindication: children's age (up to 15 years - the risk of developing Reye's syndrome in children with hyperthermia on the background of viral diseases) .

For impaired renal function

Contraindication: renal failure.

Use with caution in patients with kidney disease.

For impaired liver function

Contraindication: liver failure.

Use with caution in patients with liver disease.